Sloughing Mucosa in Esophagitis Dissecans Superficialis

Esophagitis dissecans superficialis.

c t g w m h e a e A 59-year-old woman was evaluated for dysphagia and odynophagia. She had undergone double lung transplantation 3 months earlier for hypersensitivity pneumonitis complicated by respiratory failure. At the time of endoscopy, her immunosuppressive medications consisted of tacrolimus, azathioprine, and prednisone. In addition to her immunosuppression regimen, she was taking an ora...

Bullous Pemphigoid Presenting with Esophagitis Dissecans Superficialis

An 87-year-old woman was admitted with a more than 6month history of an exacerbation of bullae. Edematous erythema and bullae were scattered throughout her extremities and trunk (Picture 1A). Serum autoantibodies against the BP-180 antigen were found. Histopathology confirmed a diagnosis of bullous pemphigoid (Picture 1B). She developed hematemesis on the fourth day after admission. Upper endos...

Esophagitis dissecans superficialis associated with bisphosphonates.

Esophagitis dissecans superficialis associated with severe clindamycin toxicity.

A 42-year-old woman with type 1 diabetes mellitus and a regular smoking habit (19 pack-years) presented with dysphagia, nausea and vomiting over the previous week, a er clindamycin treatment for infected diabetic foot ulcers. An esophagogastroduodenoscopy revealed sloughing reddish membranes in the distal esophagus, adjacent to intact healthy mucosa that were easily removed (Figs.1, 2). Histopa...

Esophagitis dissecans superficialis due to severe methotrexate toxicity.

methotrexate toxicity Esophagitis dissecans superficialis (EDS), also referred to as “sloughing esophagitis”, is associated with the sloughing of large fragments of the esophageal squamous mucosa and is a rare endoscopic finding. The etiology is often unclear but it may result from thermal, chemical, or physical insults and has been reported in association with systemic diseases such as the aut...